A ketogenic diet could positively influence the course of polycystic ovary syndrome. This is shown by a study – albeit financed by Nestlé. Diet miracle or simple rip-off?
The decision whether to have fried eggs or oatmeal for breakfast may be a matter of taste. But what if these and other eating habits can influence the course of serious diseases? Diet trends come and go, but above all, this is the ketogenic diet all the rage lately. Likewise in research: during the international symposium New Frontiers in Scientific Research, which took place recently in Barcelona, focused on the role of the ketogenic diet, in which the intake of carbohydrates is severely restricted. One Study from Italy referred to a comorbidity that occurs more frequently in overweight patients: polycystic ovary syndrome (PCOS). The aim of the study was to gain insights into whether a ketogenic diet could be beneficial for disease progression.
Das polyzystische Ovar
Led by Prof. Alessandra Gambineri, the research group from Bologna presented their results on the connection between obesity and polycystic ovary syndrome. PCOS is a chronic condition that affects approximately 10% of women of childbearing age with various symptoms. The pathophysiology of this syndrome is characterized by the interaction of three factors: androgen excessadipose tissue dysfunction and insulin resistance. These factors interact with each other and are different in each phenotype.
In the Italian study, the dysfunction of the adipose tissue is of particular importance. This central role results from the fact that substances originating from adipose tissue such as free fatty acidsproinflammatory cytokines, Adipokine, Glucocorticosteroid and Androgens can have a strong negative impact on the course of the disease, especially in the case of obesity. The thesis is visibly simple: if those affected lose weight through dieting, lipotoxicity and inflammation as well as insulin resistance are reduced. But what additional benefits can the ketgone diet show?
Farewell to carbohydrates
One speaks of a ketogenic diet in the classic sense when only small amounts of carbohydrates end up on the plate. Not eating potatoes, pasta and other sources of carbohydrates leads to a lack of these, whereupon the body burns its reserves. Should later as part of the Gluconeogenese Energy are gained, fat reserves must serve. It can through increased formation of ketone bodies a state of Ketosis occur, which at times can even be life-threatening. But what does all this bring?
In addition to previously established findings that carbohydrate restriction in diseases such as Epilepsy and Amyotrophe Lateralsklerose can be supportive are now too Typ-2-Diabetesdie non-alcoholic fatty liver disease and PCOS under discussion. Like almost all diets, the ketogenic diet is controversial. Among other things, the following are listed as possible damage to health: increase in Cholesterinspiegelskidney damage, increased Breast- and colorectal cancer riskbone damage and arteriosclerosis.
The endpoints examined in the study are based on the most common symptoms of PCOS. The research group analyzed body weight, insulin resistance, menstrual cycle, ovulation, ovarian morphology and hyperandrogenism in a group of 30 obese women (aged 18 to 45) with PCOS and insulin resistance. The women were randomly assigned to two equal-sized groups: those in the keto group followed a commercial ketogenic diet known as PronoKal for eight weeks (more on that later) and then switched to a hypocaloric diet for another eight weeks. The control group followed a hypocaloric diet for 16 weeks, although it is not clear what the calorie goal was set in either group.
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The authors of the study observed both significant weight loss and improvement in ovarian function in both groups. Women in the keto group showed a weight reduction of 12.4 kg compared to 4.7 kg in the control group (P < 0.001). Waist circumference (-8.1% vs -2.2%, P=0.004) and fat mass (-15.1% vs -8.5%, P=0.02) also decreased...