This diet changes the intestinal flora and slows down immune aging – healing practice

Diet influences the immune system via the intestinal flora

For the first time, a research team was able to demonstrate directly that a reduced calorie diet a positive effect on that immune system has and that this effect over that microbiome in the gut (intestinal flora) is mediated.

researchers of German Center for Diabetes Research could prove how one Low-calorie diet changes the gut microbiome and how this change leads to the Aging of the immune system slows down. The research results were recently published in the journal “Microbiome” presents.

consequences of being overweight

Around two billion people in the world are considered overweight. severe overweight (obesity) in turn increases the risk of numerous serious diseases such as high blood pressure, Heart attack and Typ-2-Diabetes.

Chronic inflammation from obesity

But being overweight also leads to increased chronic inflammation arise in the body. The immune system responds by sending out extra memory T and B cells. In the long run it will Immune system weakened by constant stress.

The immune system also weakens with age. This process of immune aging is called immune senescence designated. This process is accelerated in people with obesity.

Interactions with the immune system

Studies have already shown that calorie-restricted diets slow the development of metabolic diseases such as type 2 diabetes and have a positive effect on the immune system.

So far, however, it has been unclear how this effect occurs and what role the microbiome in the intestine plays. These interactions between Nutrition, microbiome, metabolism and the immune system The working group of the German Center for Diabetes Research has now been able to clarify.

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How does a low-calorie diet affect the intestinal flora?

The team analyzed how a low-calorie diet with approx 800 calories a day for eight weeks on the gut microbiome of an obese subject. In a further step, the researchers transferred the intestinal flora before and after the diet to a so-called gnotobiotic model in which no microorganisms were present.

“In this way we were able to determine the sole effects of the diet-influenced intestinal microbiome on the metabolism and the immune system”explains study author Reiner Jumpertz von Schwartzenberg.

Positive effect on glucose metabolism and immune aging

By transferring the microbiome, the working group was able to prove that the Improved glucose metabolism and herself the Reduced fat depositsif the intestinal flora was previously characterized by a low-calorie diet.

In addition, the scientists proved that the Decreased number of certain memory T and B cells. “This indicates delayed immune senescence”emphasizes the first author of the study Julia Sbierski-Kind.

“These results suggest that the positive effects of a low-calorie diet on metabolism and the immune system are mediated via the gut microbiome”sums up Sbierski-Kind.

limitation of the results

However, the working group points out that the results on the Gut microbiome of an individual based. In further investigations, the findings must first be verified on a larger group. If they are confirmed, it would be extremely interesting for medical practice.

“An improved understanding of the complex interplay between nutrition, microbiome and immune system can lay the foundations for the development of novel microbiome-based therapeutic options for the Treatment of metabolic diseases and immune diseases lay”, emphasizes Jumpertz-von Schwartzenberg in conclusion. (vb)

One diet after the other with Maite Kelly

Author and source information

This text corresponds to the requirements of medical specialist literature, medical guidelines and current studies and has been checked by medical professionals.


Graduate editor (FH) Volker Blasek


  • German Center for Diabetes Research: A low-calorie diet changes the gut microbiome and immune aging (published: 04/22/2022),
  • Sbierski-Kind, J., Spranger, J. , Jumpertz-von Schwartzenberg, R. et al.: Effects of caloric restriction on the gut microbiome are linked with immune senescence; in: Microbiome (2022). DOI: 10.1186/s40168-022-01249-4,

Important NOTE:
This article contains general advice only and should not be used for self-diagnosis or treatment. He can not substitute a visit at the doctor.

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