A low-protein diet triggers an increase in life expectancy through a single hormone – healing practice

Longer life with less protein

One Diet low in proteinbut still enough protein to avoid malnutrition, improves life expectancy and metabolic health. It has now been determined that a single hormone derived from the liver appears to be responsible for these beneficial effects.

The data from a new study involving experts from the Pennington Biomedical Research Center show that protein restriction has marked beneficial effects on lifespan and metabolic health in aging male mice and a only metabolic hormone called FGF21 is essential to the anti-aging effects of this dietary behavior.

The results can be found in the English-language journal “Nature“ to be read.

Too much protein reduces life expectancy

excessive Consumption of high-protein foods has been in the past with one increased mortality in certain age groups, the experts report.

Improving metabolism due to less protein

On the other hand, a restriction of protein intake increasingly recognized among professionals as a unique approach to Improving metabolic health accepted. However, the question arises as to the mechanisms by which this positive effect is triggered.

There is growing interest in the possibility of reducing protein or amino acid intake contributes to this positive effect. The new investigation should help to confirm this assumption and identify responsible sources.

Role of FGF21 in life expectancy

Recent results in mice suggest that Hormon Fibroblast Growth Factor 21 (FGF21) mediates the metabolic effects of protein restriction in young animals, the team found. FGF21 is a key signal that connects the body to the brain during protein restriction.

If such a signal is missing in young mice that ate a low-protein diet, the animals changed neither their eating behavior nor their metabolism, the researchers report.

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Our data suggest that FGF21 communicates with the brain, and without this signal, the mouse is unaware that it is eating a low-protein diet. As a result, the mouse cannot adaptively change its metabolism or feeding behavior‘ explains the author of the study Professor Dr. Christopher Morrison in a press release.

Beneficial effects of less protein

It turned out that one low protein diet in aged mice positive effects on metabolism by improving metabolic health, reducing frailty and increasing lifespan.

These beneficial effects were also evident when protein intake was reduced in mice middle aged was reduced, and even protected against the disadvantages of obesityaccording to the experts.

FGF21 vital to longer life

However, since these positive effects, as mentioned above, in mice, FGF21 was absentwere lost, this suggests that the action of FGF21 in the brain may improve health and life expectancy of crucial importance is.

We have previously shown that FGF21 acts in the brain to improve metabolic health in young mice fed a low-protein diet. These new data extend this work by showing that FGF21 also improves metabolic health and lengthens lifespan‘ reports the author of the study Dr. Cristal M. Hill

According to the expert, protein restriction increased life expectancy, reduced frailty, lowered body weight and obesity, and improved exercise capacity, at least in male mice.

Better glucose tolerance through less protein intake

Other beneficial effects of restricting the amount of protein ingested in the animals were one Increase in glucose tolerance and from various metabolic markers in serum, liver and adipose tissue, according to Dr. Hill.

Excess pounds can also be lost without dieting, Gütsel Online, OWL live

Conversely, mice lacking FGF21 show no metabolic responses to protein restriction early in life, and later in life they show early-onset age-related weight loss, a decreased physical performanceincreased frailty and a reduced life expectancy.

These data show that protein restriction has significant beneficial effects on lifespan and metabolic health in aging male mice, and that a…

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